CVE-2026-100845

MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.

CVSS 4.0

8.5CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:P/VC:H/VI:H/VA:H/SC:N/SI:N/SA:N

CVSS 3.1

7.8CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H

EPSS

0.2% chance of exploitation in the next 30 days; higher than 10% of CVEs (scores of 2026-10-25)

CWE

CWE-502

Published

2026-09-27

Modified

2026-09-30

Record from

the NVD, synced 2026-10-19

Affected

• project-monai:monai

Packages (OSV)

References

• https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-wg9g-w2j2-8pgr
• https://www.vulncheck.com/advisories/monai-before-1.6.0-remote-code-execution-via-numpyreader
• https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-wg9g-w2j2-8pgr

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